In the wake of the 2024 U.S. elections, cannabis reform has reached a crossroads, marked by victories and setbacks that reveal the complexities of the legalization landscape. Florida’s Amendment 3 garnered majority support at 56%, but due to the state’s 60% supermajority requirement, it narrowly failed, showing the strong yet complicated path for recreational legalization in traditionally conservative states. Meanwhile, Nebraska achieved a significant win with Initiatives 437 and 438, which introduced medical cannabis legalization and a regulatory framework for businesses, despite potential delays from legal challenges. In the Dakotas, efforts to pass recreational measures fell short, with North Dakota’s Measure 5 and South Dakota’s Measure 29 both defeated. The broader election results underscore a mixed national stance on cannabis reform—where medical use frameworks continue to expand, yet recreational legalization encounters legal and political barriers. This episode unpacks the progress, resistance, and shifting public opinion shaping the future of cannabis in America.