The Department of Pharmacology at The University of Arizona Part 2

The Department of Pharmacology at The University of Arizona Part 2

The Department of Pharmacology at The University of Arizona is comprised of faculty, fellows, students, and technical staff working together to understand how chemicals influence human disease. Some chemicals and drugs are used to treat human diseases while others are known to cause human diseases.

The Department of
Dr. John Streicher earned his Ph.D. from UCLA in 2009, in the lab of Dr. Yibin Wang, where he studied the signal transduction cascades linking heart stress to heart failure. He then went on to a postdoctoral fellowship with Dr. Laura Bohn at Scripps-Florida, where he studied biased signaling at the opioid receptors. In 2012, he joined the faculty at the University of New England, where he combined the threads of his training into a research program focused on the signal transduction cascades of the opioid, cannabinoid, and other brain-relevant receptors, mostly in the context of pain. He joined the faculty of the University of Arizona in 2015, where he continues his work today.

Dr. Streicher is interested in understanding the molecular signal transduction cascades downstream of the opioid receptors. His research program focuses on finding new signaling regulators of the opioid receptors, determining their molecular mechanisms, and then determining how these molecular mechanisms result in changes to opioid-induced analgesia and side effects in different pain states. He further uses this information to create novel drug discovery strategies to create new opioid drugs without the side effects drawbacks of current drugs, like an addiction. His research approaches encompass the creation of pain states such as post-surgical pain and the measurement of opioid analgesia in these pain states, combined with state-of-the-art approaches to modulate novel signaling regulators in mice including CRISPR/Cas9 in the brain and spinal cord. He also screens drugs in medium- to high-throughput formats in cell models to find and develop new analgesic drugs.

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